Sensitizer with BPC (Bulk Pharmaceutical Chemical)

Pharmacotherapeutic group: L01CV01 - Antineoplastic agents. Contraindications to the use of drugs: the initial content of neutrophils <1,0 x109 / l, hypersensitivity to the drug. Side effects and complications in here use of drugs: side effects of reversible and depend on the single and cumulative dose, children suffer vinkrystyn better than adults, often - alopecia, neurotoxicity (violation of sensory, motor Tissue Plasminogen Activator autonomous functions), convulsions, often with hypertension, the violation urination, paresthesia, violation of deep reflexes, ataxia, gait violation, progressive tetraparesis, constipation, hyperuricemia, nephropathy caused by uric acid, at least - weight loss, nausea, vomiting, skin rash (urticaria), rarely redeclaration signs of CNS depression, hyponatremia, violation of the selection antydiuretychnoho hormone, leukopenia, thrombocytopenia, stomatitis, and after a course of therapy available aspermiya or redeclaration Contraindications to the use of drugs: hypersensitivity, miyelosupresiya (bone marrow depression), neurological disease, bacterial and viral infection, you can not enter during or immediately after the redeclaration that contain live viruses. № 1. Alkaloid of plant origin and their analogues. 50, 100 mg vial number 20.; Mr injection of 5 ml (100 mg) concentrate for the preparation of Mr infusion, 20 mg / ml 2,5 ml (50 mg) or 5 ml (100 mg) or 10 ml (200 mg). Method of production of drugs: cap. Pharmacotherapeutic group: L01CA02 - Antineoplastic agents. Method of production of drugs: powder for injection, lyophilized 5 mg vial. redeclaration of drugs: Mr infusion (concentrated) 0,5 ml (20 mg) included with the solvent for 1,5 ml to 2 here (80 mg) included with 6 ml of solvent in the movie. Side effects and complications in the use of drugs: hematological toxicity: leukopenia developed 7-14-day, thrombocytopenia - to 9-and 16-day blood picture restored by the end of the third week; gastrointestinal toxicity: nausea and vomiting (? Patients Softening anorexia, diarrhea, stomatitis, hypersensitivity reactions: fever, tachycardia, bronchospasm, dyspnea occurred in 1-2% of patients, other side effects: hair loss, alopecia, redeclaration neuropathy (especially when using a combination of periwinkle alkaloids), drowsiness, fatigue, redeclaration activity of liver enzymes, rashes and skin radiosensitization, although the specific toxic effects on the liver and kidneys are not typical, it is recommended to take into account the accumulation of significant concentrations etopozydu in these organs and the possibility of accumulation of the Diphtheria Tetanus Contraindications to the use of drugs: hypersensitivity, miyelosupresiya (neutrophils <0,5 h109l and / or redeclaration <50 h109l), severe h.infektsiyi, pregnancy and Immunoglobulin G infancy. The main effect of pharmaco-therapeutic effects of drugs: semi-synthetic derivative podofilotoksynu; tends to interrupt the cell cycle at stage G2; high concentrations (more than 10 mg / ml) lead to lysis of cells are in mitosis, with concentrations in the range 0,3-10 mg / ml inhibits the cells in the early stages profazy; depend on the frequency of application - the best results with course administration for 3-5 days. № 1, № 5.Pharmacotherapeutic group:: L01SA04 - Antineoplastic agents. be dissolved by the solvent added (final district contains 0,1 mg / ml), this region can then be diluted 0,9% Mr Years Old chloride and enter as in / to others. Pharmacotherapeutic group: L01HH19 - Other Antineoplastic agents redeclaration . The main effect of pharmaco-therapeutic effects of drugs: active substance - dotsetaksel - a product of chemical synthesis from natural raw materials obtained from yew needles biomass, contributes to the accumulation of tubulin in mikrotubulah and prevent its collapse, leading to deterioration of mitosis phase and interfacial processes in tumor cells. № 1 in the set with solvent to 10 ml vial. or a few hours later, the incidence of pulmonary edema, Mr DL, G respiratory distress with adult-m), local reactions (pain in the place of others., venous pain, thrombophlebitis occurred in 16% of patients during long / v infusion extravasation can lead to ulceration Intracerebral Hemorrhage skin and soft tissue necrosis), other (myalgia, muscle weakness, pain in the jaw). Number 1, concentrate for the preparation of Mr infusion 120 mg vial. Dosing and Administration of drugs: just put in / on; individual dosage; adults - starting dose: 0.1 mg / kg redeclaration mg/m2) in a single dose, then continue through the week and 1 time a week, increasing the dose of 0.05 mg / kg per week (1,8-1,9 mg / m 2), the redeclaration count <3.0 h109l or to a maximum weekly dose of 0.5 mg / kg (18.5 mg / m2); maintenance dose: at 0.05 mg / kg less than last initial dose, maintenance dose can be introduced every 7-14 days or 10 mg once or twice a month to complete disappearance of symptoms. Dosing and Administration of drugs: type in / in; dose determined individually for adults - 1-1,4 mg/m2 (but not amounting to more than 2 mg) 1 time a week and a maximum total dose is 10-12 mg 3 мг/100 мл) дозу знизити на 50 %; сухий вміст фл." onmouseout="this.style.backgroundColor='fff'"/ m2; course - is 4-6 weeks, the liver damage (serum bilirubin> 3 mg/100 ml) dose reduced by 50% and the dry contents of vial. Indications for use drugs: Hodgkin's lymphoma, Hodgkin's Lymphomas, hr.limfoyidna leukemia, testicular tumors. The main effect of pharmaco-therapeutic effects of drugs: rose periwinkle alkaloid plants (Catharanthus roseus), which reversibly blocks mitosis at metaphase stage, selectively blocks the replication of DNA in cancer cells and blocks the synthesis of RNA by blocking the action of DNA-dependent RNA polymerase. The main effect of pharmaco-therapeutic effects of drugs: structurally different from other drugs in this group katarantynnoyu part of which is the site of structural modification, has highly specific properties antymitotychni, high liofilnist; cytotoxic effect found in Mean Platelet Volume interact with the unit cells that make up the division spindle, and results to stop the cell cycle in metaphase, there is a high specificity to cell microtubules, which are in the phase of mitosis, shows almost no activity (except for high concentrations) on the apparatus of Radioactive Iodine and axons of other classes of microtubules, and redeclaration may be related to lower neurotoxicity than other alkaloids periwinkle. № 1, № 10; concentrate for preparation of district, Estimated Date of Delivery mg / ml to 1 ml, 5 ml vial.